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NIH Osteoporosis and Related Bone Diseases
Osteogenesis imperfecta (OI) is a genetic disorder characterized by bones that break easily. OI is highly variable. Its signs and symptoms range from mild to severe. In addition to fractures (broken bones), people with OI sometimes have muscle weakness, loose joints (joint laxity), curvature of the spine (scoliosis), brittle teeth (dentinogenesis imperfecta), and hearing loss.
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